Laboratory of Pathology

Elucidation of human disorders using hydrogel and the medical application

Research Theme: Analysis of cellular responses to functional polymer gels and their medical application
Research Keywords: biomaterial, cancer stem cell, molecular targeted therapy, regenerative medicine, cartilage regeneration, neuroregeneration

Staff

TSUDA Masumi Associate Professor

Overview of Research and Education

Research Contents: Students acquire basic knowledge of basic medicine, clinical medicine, and regenarative medicine necessary for medical application of soft matter (synthetic polymer hydrogel). Particularly, by analysing cell phenomena and in vivo reactivity on soft matter that mimics in vivo environment, students deepen thier understanding of diseases in the fied of cancer treatment, artifical cartilage, and regenerative medicine. Ultimately, we aim to contribute to medical development toward an advanced precision medicine and aging society, by fusing medicine and soft matter.

Laboratory of Pathology (pdf)

Charge

Charge (GS):
Graduate School of Life Science, Division of Soft Matter, Soft Matter Medical Science

Contact

Address: 〒060-8638
Department of Cancer Pathology, Faculty of Medicine, Hokkaido University,
N15 W7, Kita-ku, Sapporo, Japan
Phone: 011-706-5053
Fax: none
Email: tsudam*med.hokudai.ac.jp(Please replace*with @ when sending e-mail.)

Department of Cancer Pathology, Graduate School of Medicine, Hokkaido University

Representative Publications

Suzuki R, Yamasoba D, Kimura I, Wang L, Kishimoto M, Ito J, Morioka Y, Nao N, Nasser H, Uriu K, Kosugi Y, Tsuda M, Orba Y, Sasaki M, Shimizu R, Kawabata R, Yoshimatsu K, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Sawa H, Ikeda T, Irie T, Matsuno K, Tanaka S, Fukuhara T, Sato K. Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant. Nature 110:747-760, 2022

Saito A, Irie T, Suzuki R, Maemura T, Nasser H, Uriu K, Kosugi Y, Shirakawa K, Sadamasu K, Kimura I, Ito J, Wu J, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Loeber S, Tsuda M, Wang L, Ozono S, Butlertanaka EP, Tanaka YL, Shimizu R, Shimizu K, Yoshimatsu K, Kawabata R, Sakaguchi T, Tokunaga K, Yoshida I, Asakura H, Nagashima M, Kazuma Y, Nomura R, Horisawa Y, Yoshimura K, Takaori-Kondo A, Imai M; Genotype to Phenotype Japan (G2P-Japan) Consortium, Tanaka S, Nakagawa S, Ikeda T, Fukuhara T, Kawaoka Y, Sato K. Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation. Nature 602: 300-306, 2021

Suzuka J, Tsuda M, Wang L, Kohsaka S, Kishida K, Semba S, Sugino H, Aburatani S, Frauenlob M, Kurokawa T, Kojima S, Ueno T, Ohmiya Y, Mano H, Yasuda K, Gong JP, Tanaka S. Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels. Nat Biomed Eng. 5:914-925, 2021

Yachi K, Tsuda M, Kohsaka S, Wang L, Oda Y, Tanikawa S, Ohba Y, Tanaka S. miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition. Signal Transduct Target Ther. 3: 33, 2018.

Fujioka Y, Tsuda M, Nanbo A, Hattori T, Sasaki J, Sasaki T, Miyazaki T, Ohba Y. A Ca(2+)-dependent signaling circuit regulates influenza A virus internalization and infection. Nat Commun, 4, 2763, 2013

Watanabe T, Tsuda M, Makino Y, Konstantinou T, Nishihara H, Majima T, Minami A, Feller SM, Tanaka S. Crk adaptor protein induced-phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration. Cell Res, 19, 638-650, 2009

Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.kzHw9KIOBcsqR-g1pQ3MdA==.html)