機能再生医学研究室

機能性マテリアルを臨床応用へ

研究テーマ: 軟骨変性・軟骨再生のメカニズムを解明する。/ 運動器疾患に対する革新的治療法を開発し、臨床応用を目指す
研究キーワード: 整形外科、関節外科、再生医療、運動器、動物モデル、足場材料、軟骨、骨、半月板、バイオマテリアル、ソフトマター、臨床応用、橋渡し研究

スタッフ

小野寺智洋准教授

研究・教育内容

研究内容：高い生理活性を持ち、未分化細胞の足場となるようなソフトマターマテリアルを開発し、運動器疾患分野における臨床応用を目指す。臨床応用への橋渡しを担う動物実験・臨床研究を実行し、得られた結果を元にマテリアルの実用化を行う。

機能再生医学研究室（pdf）

担当学部・大学院

大学院担当:
大学院生命科学院，ソフトマター専攻，ソフトマター医科学

お問合せ

研究室所在地: 〒060-8648
札幌市北区北14条西5丁目
医学研究院機能再生医学分野
整形外科学教室
電話番号: 011-706-5935
Fax番号: なし
Email: tomozou*med.hokudai.ac.jp（*を半角@に変えて入力ください）

研究室ウェブサイト

代表的な研究業績

Kentaro Homan, Tomohiro Onodera, Hisatoshi Hanamatsu, Jun-Ichi Furukawa, Daisuke Momma, Masatake Matsuoka, Norimasa Iwasaki., Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis. Elife 2024/3

Onodera T, Momma D, Matsuoka M, Kondo E, Suzuki K, Inoue M, Higano M, Iwasaki N., Single-step ultra-purified alginate gel implantation in patients with knee chondral defects. Bone Joint J. 2023/8

Yamaguchi J, Onodera T, Homan K, Liang X, Matsuoka M, Miyazaki T, Yoshiaki H, Saito M, Iwasaki N., Optical coherence tomography evaluation of the spatiotemporal effects of 3D bone marrow stromal cell culture using a bioreactor. J Biomed Mater Res B Appl Biomater. 2022/08

Hosokawa Y, Onodera T, Homan K, Yamaguchi J, Kudo K, Kameda H, Sugimori H, Iwasaki N., Establishment of a New Qualitative Evaluation Method for Articular Cartilage by Dynamic T2w MRI Using a Novel Contrast Medium as a Water Tracer. Cartilage. 2022/08

Liang D, Onodera T, Hamasaki M, Hishimura R, Homan K, Xu L, Tian Y, Kanai S, Iwasaki N., Quantification of Cartilage Surface Degeneration by Curvature Analysis Using 3D Scanning in a Rabbit Model. Cartilage. 2021/12

Xu L, Urita A, Onodera T, Hishimura R, Nonoyama T, Hamasaki M, Liang D, Homan K, Gong JP, Iwasaki N., Ultrapurified Alginate Gel Containing Bone Marrow Aspirate Concentrate Enhances Cartilage and Bone Regeneration on Osteochondral Defects in a Rabbit Model. Am J Sports Med. 2021/07

Momma D, Onodera T, Kawamura D, Urita A, Matsui Y, Baba R, Funakoshi T, Kondo M, Endo T, Kondo E, Iwasaki N., Acellular Cartilage Repair Technique Based on Ultrapurified Alginate Gel Implantation for Advanced Capitellar Osteochondritis Dissecans. Orthop J Sports Med. 2021/3

Onodera T, Baba R, Kasahara Y, Tsuda T, Iwasaki N., Therapeutic effects and adaptive limits of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models. Regen Ther. 2020/02

Kim W, Onodera T, Kondo E, Terkawi MA, Homan K, Hishimura R, Iwasaki N., Which Contributes to Meniscal Repair, the Synovium or the Meniscus? An In Vivo Rabbit Model Study With the Freeze-Thaw Method. Am J Sports Med. 2020/1

Hontani K, Onodera T, Terashima M, Momma D, Matsuoka M, Baba R, Joutoku Z, Matsubara S, Homan K, Hishimura R, Xu L, Iwasaki N, Chondrogenic differentiation of mouse induced pluripotent stem cells (iPSCs) using the three-dimensional culture with ultra-purified alginate gel (UPAL gel)., Journal of biomedical materials research. Part A 2019/01

Hishimura R, Onodera T, Hontani K, Baba R, Homan K, Matsubara S, Joutoku Z, Kim W, Nonoyama T, Kurokawa T, Gong JP, Iwasaki N., Osteochondral Autograft Transplantation Technique Augmented by an Ultrapurified Alginate Gel Enhances Osteochondral Repair in a Rabbit Model., The American journal of sports medicine. 363546518817527 2019/01

Kim W, Onodera T, Kondo E, Kawaguchi Y, Terkawi MA, Baba R, Hontani K, Joutoku Z, Matsubara S, Homan K, Hishimura R, Iwasaki N, Effects of Ultra-Purified Alginate Gel Implantation on Meniscal Defects in Rabbits., The American journal of sports medicine 363546518816690 2018/12

Momma D, Onodera T, Homan K, Matsubara S, Sasazawa F, Furukawa J, Matsuoka M, Yamashita T, Iwasaki N., Coordinated existence of multiple gangliosides is required for cartilage metabolism., Osteoarthritis Cartilage 2018/11

Baba R, Onodera T, Matsuoka M, Hontani K, Joutoku Z, Matsubara S, Homan K, Iwasaki N, Bone Marrow Stimulation Technique Augmented by an Ultrapurified Alginate Gel Enhances Cartilage Repair in a Canine Model., The American journal of sports medicine 46(8) 1970-1979 2018/07

北大研究者総覧参照
（https://researchers.general.hokudai.ac.jp/profile/ja.uAO.-VWRTctYkSPLUjrOeg==.html）