スタッフ

龔 剣萍教授 (GONG Jian Ping)

研究室
ソフト&ウェットマター研究室
研究テーマ
機能性高分子ゲルの創製と生体材料への応用
研究キーワード

ソフトマター、ソフトマテリアル、ゲル、強度、靭性、破壊、接着、摩擦、潤滑、人工軟骨、細胞足場、生体材料

研究内容

生体は骨、歯、爪をのぞけば、やわらかい軟組織（Tissue）だけで構成されている。生体の優れた機能のほとんどはこの軟組織が担っている。 筋肉が鋭敏で高効率なエンジンとして力を生み、強靱な腱がその力を骨に伝えて関節を動かし、軟骨が大荷重に耐えながら関節の滑らかな動きを保障する。 生体軟組織のような優れた機能を有する人工材料を創製し、軟骨や筋肉様な生体代替軟組織へ応用することが、私がチャレンジする課題である。

生体軟組織は生体高分子(DNA、たんぱく質、糖鎖など)と30〜80％の水から構成され、ソフト＆ウェットな物質系に属する。生体軟組織の優れた機能の創発原理はまだ分かっていないが、 そのソフト＆ウェットな物質状態に根本原因があると考えられる。高分子ゲルは、生体軟組織と同じくソフト＆ウェットな物質系に属する。 この点に着目し、我々の研究室は、「生体軟組織の複合・秩序・階層構造をヒントに機能性ゲルを創製」⇔「そうしたゲルに対する研究をもとに生体軟組織の機能創発の原理を解明」という循環の中で、 軟骨、腱、筋肉などの生体軟組織に匹敵する高強度・高機能ゲルを開発し、医療分野を始め、さまざまな分野への応用を目指している。

担当学部・大学院

メッセージ

ソフト＆ウェットマター科学は、化学・物理学・生物学、材料科学などの分野を跨ぐ新しい分野です。 生体組織の構造をヒントに、生体組織に匹敵する機能を持つゲル作りに、その原理究明に、さらにその応用に興味を持つ学生ならどなたでもウェルカムです。

代表的な研究業績

Original papers

  1. J. P. Gong, Y. Katsuyama, T. Kurokawa, Y. Osada, “Double Network Hydrogels with Extremely High Mechanical Strength”, Advanced Materials, 15, 1155-1158 (2003). (top 1% paper)
  2. Md. A. Haque, G. Kamita, T. Kurokawa, J. P. Gong, “Unidirectional Alignment of Lamellar Bilayer in Hydrogel: One-Dimensional Swelling, Anisotropic Modulus, and Stress/Strain Tunable Structural Color”, Advanced Materials, 22, 5110-5114 (2010).
  3. Md. A. Haque, T. Kurokawa, G. Kamita, J. P. Gong, “Lamellar Bilayers as Reversible Sacrificial Bonds To Toughen Hydrogel: Hysteresis, Self-Recovery, Fatigue Resistance, and Crack Blunting “, Macromolecules, 44, 8916-8924 (2011).
  4. T. L. Sun, T. Kurokawa, S. Kuroda, A. B. Ihsan, T. Akasaki, K. Sato, M. A. Haque, T. Nakajima, J. P. Gong “Physical hydrogels composed of polyampholytes demonstrate high toughness and viscoelasticity”, Nature Materials, 12, 932-937 (2013). (top 1% paper)
  5. F. Luo, T. L. Sun, T. Nakajima, T. Kurokawa, Y. Zhao, K. Sato, A. B. Ihsan, X. F. Li, H. L. Guo, J. P. Gong, “Oppositely Charged Polyelectrolytes Form Tough, Self-healing and Rebuildable Hydrogels”, Advanced Materials, 27, 2722-2727 (2015). (top 1% paper)
  6. H. J. Zhang, T. L. Sun, A. K. Zhang, Y. Ikura, T. Nakajima, T. Nonoyama, T. Kurokawa, O. Ito, H. Ishitobi, J. P. Gong, “Tough Physical Double-Network Hydrogels Based on Amphiphilic Triblock Copolymers,” Advanced Materials, 28, 4884-4890 (2016). (top 1% paper)
  7. T. Matsuda, T. Nakajima, Y. Fukuda, W. Hong, T. Sakai, T. Kurokawa, U. Chung, J. P. Gong, Yielding Criteria of Double Network Hydrogels, Macromolecules, 49(5), 1865-1872 (2016).
  8. T. L. Sun, F. Luo, W. Hong, K. Cui, Y. Huang, H. Zhang, D. R. King, T. Kurokawa, T. Nakajima, J. P. Gong, Bulk Energy Dissipation Mechanism for the Fracture of Tough and Self-Healing Hydrogels, Macromolecules, 50(7), 2923-2931 (2017).
  9. K. Cui, T. L. Sun, X. Liang, K. Nakajima, Y. N. Ye, L. Chen, T. Kurokawa, J. P. Gong, Multiscale Energy Dissipation Mechanism in Tough and Self-Healing Hydrogels, Physical Review Letters (2018).
  10. P. Rao, T. L. Sun, L. Chen, R. Takahashi, G. Shinohara, H. Guo, D. R. King, T. Kurokawa, J. P. Gong, Tough Hydrogels with Fast, Strong, and Reversible Underwater Adhesion Based on a Multi-Scale Design, Advanced Materials, 30(32), 1801884 (2018).
  11. T. I. Mredha, T. Nonoyama, T. Nakajima, Y. Z. Guo, T. Kurokawa, J. P. Gong, “A Facile Method to Fabricate Anisotropic Hydrogels with Perfectly Aligned Hierarchical Fibrous Structures”, Advanced Materials, 30(9), 1704937 (2018).
  12. R. Takahashi, T. L. Sun, Y. Saruwatari, T. Kurokawa, D. R. King, J. P. Gong, “Creating Stiff, Tough, and Functional Hydrogel Composites with Low Melting Point Alloys”, Advanced Materials, 30, 1706885 (2018).
  13. H. Guo, T. Nakajima, D. Hourdet, A. Marcellan, C. Creton, W. Hong, T. Kurokawa, J. P. Gong, Hydrophobic Hydrogels with Fruit-Like Structure and Functions, Advanced Materials, 31(25), 1900702 (2019)
  14. H. Fan, J. Wang, Z. Tao, J. Huang, P. Rao, T. Kurokawa, J. P. Gong, “Adjacent Cationic-Aromatic Sequences Yield Strong Electrostatic Adhesion of Hydrogels in Seawater”, Nature Communications, 10, 5127 (2019).
  15. T. Matsuda, R. Kawakami, R. Namba, T. Nakajima, J. P. Gong, “Mechanoresponsive Self-growing Hydrogels Inspired by Muscle Training”, Science, 363, 504-508 (2019). (top 1% paper)
  16. X. Li, K. Cui, T. L. Sun, L. Meng, C. Yu, L. Li, C. Creton, T. Kurokawa, J. P. Gong, Mesoscale Bicontinuous Networks in Self-healing Hydrogels Delay Fatigue Fracture, Proc. Natl. Acad. Sci. U.S.A., 117(14), 7606-7612 (2020)
  17. T. Nonoyama, Y. W. Lee, K. Ota, K. Fujioka, W. Hong, J. P. Gong, Instant Thermal Switching from Soft Hydrogel to Rigid Plastics Inspired by Thermophile Proteins, Advanced Materials, 32(4), 1905878 (2020).
  18. W. Cui, D. R. King, Y. Huang, L. Chen, T. L. Sun, Y. Guo, Y. Saruwatari, C.-Y. Hui, T. Kurokawa, J. P. Gong, Fiber‐Reinforced Viscoelastomers Show Extraordinary Crack Resistance That Exceeds Metals, Advanced Materials, 32(31), 1907180 (2020)
  19. T. Matsuda, R. Kawakami, T. Nakajima, J. P. Gong, “Crack Tip Field of a Double-Network Gel: Visualization of Covalent Bond Scission through Mechanoradical Polymerization”, Macromolecules, 53, 5787-8795 (2020).
  20. C. Yu, H. Guo, K. Cui, X. Li, Y. N. Ye, T. Kurokawa, J. P. Gong, “Hydrogels as Dynamic Memory with Forgetting Ability,” Proc. Natl. Acad. Sci. U.S.A., 117(32), 18962-18968 (2020).
  21. Y. N. Ye, K. Cui, W. Hong, X. Li, Ch. Yu, D. Hourdet, T. Nakajima, T. Kurokawa, J. P. Gong, “Molecular Mechanism of Abnormally Large Nonsoftening Deformation in a Tough Hydrogel”, Proc. Natl. Acad. Sci. U.S.A., 118, e2014694118 (2021).
  22. X. Li, K. Cui, T. Kurokawa, Y. N. Ye, T. L. Sun, C. Yu, C. Creton, J. P. Gong, “Effect of Mesoscale Phase Contrast on Fatigue-Delaying Behavior of Self-Healing Hydrogels”, Science Advances, 7, eabe8210 (2021).
  23. Z. Wang, X. Zheng, T. Ouchi, T. B. Kouznetsova, H. K. Beech, S. Av-Ron, T. Matsuda, B. H. Bowser, S. Wang, J. A. Johnson, J. A. Kalow, B. D. Olsen, J. P. Gong, M. Rubinstein, S. L. Craig, “Toughening hydrogels through force-triggered chemical reactions that lengthen polymer strands,” Science, 374, 193-196 (2021).
  24. X. Y. Li, J. P. Gong, “Role of Dynamic Bonds on Fatigue Threshold of Tough Hydrogels,” PNAS, 119(20), e2200678119 (2022).
  25. Z. J. Wang, J. Jiang, Q. Mu, S. Maeda, T. Nakajima, J. P. Gong, “Azo-Crosslinked Double-Network Hydrogels Enabling Highly Efficient Mechanoradical Generation,” J. Am. Chem. Soc. 144, 7, 3154–3161(2022).
  26. Q.-F. Mu, K.-P. Cui, Z. J. Wang, T. Matsuda, W. Cui, H. Kato, S. Namiki, T. Yamazaki, M. Frauenlob, T. Nonoyama, M. Tsuda, S. Tanaka, T. Nakajima, J. P. Gong, “Force-triggered rapid microstructure growth on hydrogel surface for on-demand functions,” Nature Communications, 13, Article number: 6213 (2022).
  27. R. Kiyama, M. Yoshida, T. Nonoyama, T. Sedlačík, H. Jinnai, T. Kurokawa, T. Nakajima, J. P. Gong, “Nanoscale TEM Imaging of Hydrogel Network Architecture,” Advanced Materials, 35(1), 2208902 (2023).
  28. Gumi Wei, Yumeko Kudo, Takahiro Matsuda, Zhi Jian Wang, Qi Feng Mu, Daniel R. King, Tasuku Nakajima, Jian Ping Gong, “Sustainable mechanochemical growth of double-network hydrogels supported by vascular-like perfusion”, Materials Horizons, 2023,10, 4882-4891(2023).
  29. Xueyu Li, Kunpeng Cui, Yong Zheng, Ya Nan Ye, Chengtao Yu, Wenqi Yang, Tasuku Nakajima, Jian Ping Gong, “Role of hierarchy structure on the mechanical adaptation of self-healing hydrogels under cyclic stretching”, Science Advances, 9, 51 (2023).
  30. Yiran Li, Bin Xue, Jiahui Yang, Julong Jiang, Jing Liu, Yanyan Zhou, Junsheng Zhang, Mengjiao Wu, Yuan Yuan, Zhenshu Zhu, Zhi Jian Wang, Yulan Chen, Yu Harabuchi, Tasuku Nakajima, Wei Wang, Satoshi Maeda, Jian Ping Gong, Yi Cao, “Azobenzene as a photoswitchable mechanophore,” Nature Chemistry, 16, 446–455 (2023).

Review papers

  1. J. P. Gong, “Why are double network hydrogels so tough?” Soft Matter, 6, 2583-2590 (2010). (top 1% paper)
  2. Md. A. Haque, T. Kurokawa, J. P. Gong, “Super tough double network hydrogels and their application as biomaterials”, Polymer, 53(9), 1805-1822 (2012). (top 1% paper)
  3. J. P. Gong, “Materials both Tough and Soft”, Science, 344, 161-162 (2014). (top 1% paper)
  4. H. L. Fan, J. P. Gong, “Fabrication of Bioinspired Hydrogels: Challenges and Opportunities,” Macromolecules, 53(8), 2769-2782 (2020). (top 1% paper)
  5. H. L. Fan, J. P. Gong, “Bioinspired Underwater Adhesives”, Advanced Materials, 33(44), 2102983 (2021). (top 1% paper)
  6. R. Long, C.-Y. Hui, J. P. Gong, E. Bouchbinder, “The Fracture of Highly Deformable Soft Materials: A Tale of Two Length Scales”, Annual Review of Condensed Matter Physics, 12(1), 71-94 (2021). (top 1% paper)

備考

＜オフィスアワー＞
・訪問受け入れ日時：講義期間中はいつでも
・居室：次世代棟4階
※不在の場合があるため下記メールアドレスへ事前連絡の上来室してください。
gong[at]sci.hokudai.ac.jp

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